Add MS 56148

FLEMING PAPERS. Vol. XLIII. 27 June 1917-27 Jan.1918.

ff. ii +155. 323 x 196mm. Army notebook ‘129’ with a hard, green cover. This notebook contains many loose sheets.

Notebook includes:

Section one:

1. ff. 1, 4v-8. Series of experiments examining the effect of Dakins solution on leucocytes, dressings, its strength after exposure to air and its effect on trypsin; 5 April-23 Aug. 1917.

2. f. 9. Experiments with Dichlormine T, in particular an experiment with a small hole in [Robert] Cruickshank’s ankle; 14 Jan. 1918.

3. f. 13. Experiment to examine the effect of glucose on growth of perfringens in serum; n.d.

4. ff. 14-18. Experiments with Brilliant Green on its inhibitory action on the growth of staphylococcus and coli in serum, its effect on leucocytes, its inhibitory power in serum and its absorption by gauze. Includes a piece of round filter paper showing absorption of various dilutions of Brilliant Green; 4 July-14 Sept. 1917.

5. f. 19. Work on artificial wounds and treatment with Brilliant Green and flavine; n.d.

6. ff. 20-22. Experiments testing the absorption of different antiseptics in cotton wool and gauze; 14-22 Sept. 1917.

7. ff. 25-28. Experiments with picric acid on its effect on leucocytes and its absorption by gauze, includes a round piece of filter paper; 6 July-23Aug. 1917.

8. ff. 31, 36. Experiments examine the effect of HgCl2 and carbolic acid on leucocytes; 24-25 July 1917.

Section two: 28 June-7 Aug. 1917.

ff. 41v-88, 140-145. Cressy’s Hole

Work includes a description and diagram of the wound and a series of tests with normal salt, 5% salt, eusol, albumen, Dakins solution, Carrell’s treatment, 5% hypertonic salt, flavine and Lock’s solution to examine their antiseptic action.

Section three:

1. ff. 89-92. Work on the inhibitory power of HgCL2, eusol, carbolic, malachite green and iodine on coli, proteus and staphylococcus; n.d.

2. ff. 93-94. Experiments on the absorption of gauze using iodine and the percolation of cotton fabrics and dyes; n.d.

3. ff. 98-109, 147-149. A range of experiments with sodium silico fluoride on its inhibitory action, antiseptic action and antiseptic action in Lock’s solution, including graphs and a pamphlet with articles on a range of subjects from sodium fluosilicate to a new mounting medium for microscopes; 29 Aug. 1917.

4. ff. 112-115. Experiments examining the inhibitory action of chemisol; 4 Oct. -16 Nov. 1917.

5. ff.119-121, 150. Series of experiments examining the gas formation of various bacteria, results illustrated using graphs and diagrams of test tubes; 6 Oct. 1917.

6. ff. 122-123. Experiments examining the inhibitory power of pyronin on B. coli in serum and on leucocytes; 10 Oct. 1917.

7. ff. 125-129. Experiments with asbestos wool examining its influence on growth of aerobes, on antiseptic action and on the growth of B. coli in broth, results illustrated using graphs; 26 Oct. 1917.

8. f. 153. Letter to Fleming from an employee of Parke, Davis and Company, dated 27 March 1923. He asks Fleming to take a swab from his assistant, Mr Fardon, to identify the cause of a ‘bad throat’. Fleming has used the letter to make notes on different strengths of certain chemicals.

9. f. ii. Notes by Fleming on eyepieces for a micrometer; n.d.

Links with other notebooks:

56149: No direct links, the work on the treatment of wounds with

antiseptics could be viewed as a starting point for further work

56223: Work on the effect of Dakins, Dichloramine T. and eusol on wounds, diagrams of test tubes relating to experiments with B. welchii and B. sporogenes and work on Cressy’s hole

56224: HgCl2

includes:

• f. ii Scientific equipment: Notes by A. Fleming on eyepieces for micrometers and microscopes: n.d.
• ff. 1, 4-8 Biochemistry: Experiments by A. Fleming rel. to trypsin: 1917-1932, n.d.
• ff. 1, 4-8, 14-18, 25-28, 31, 36 Haematology: Experiments by A. Fleming rel. to leucocytes: 1917-1948, n.d.
• ff. 1, 4v-8, 41-88, 140-145 Pharmacology antiseptics: Experiments by A. Fleming using Dakin's Solution: 1916-1917.
• ff. 1, 4v-9, 14-18, 20-22, 31, 36, 89-92, 98-109, 125-129, 147-149 Pharmacology antiseptics: Experiments and notes by A. Fleming: 1916-1949, n.d.
• f. 9 Robert Cruickshank, bacteriologist: Experiment by A. Fleming using Dichloramine T (antiseptic) on a hole in Cruickshank's ankle, 14 January: 1918.
• ff. 14-19 Pharmacology antiseptics: Experiments by A. Fleming using Brilliant Green: 1915-1934.
• f. 19 Pharmacology: Experiments by A. Fleming rel. to artificial wounds, includes diagrams: 1916-1917.
• ff. 25-28 Pharmacology antiseptics: Experiments by A. Fleming rel. to picric acid: 1917-1924.
• ff. 25-28, 93-94 Pharmacology: Experiments by A. Fleming rel. to antiseptics and their absorption by gauze, includes diagrams: 1917.
• ff. 31, 36, 89-92 Pharmacology antiseptics: Experiments by A. Fleming rel. to HgCl2 (mercuric chloride): 1917-1928, n.d.
• ff. 41v-88, 140-145 Pharmacology: Experiments by A. Fleming using a range of antiseptics with a wound entitled 'Cressy's Hole', 28 June-7 August: 1917.
• ff. 112-115, 122-123 Chemical process: Experiments by A. Fleming rel. to inhibition: 1917-1942.
• ff. 119-121, 150 Bacteriology: Experiments by A. Fleming rel. to gas formation by bacteria, includes graphs and diagrams: 1917.