Add MS 56158

FLEMING PAPERS. Vol. LIII. 12 March 1924-10 Jan. 1928.

ff. ii + 55. 277 x 225mm. Ring binder with hard, black cover. It was advertised as a ‘scholastic notebook’.

Label inside the cover for ‘W. Isacke, Manufacturing Stationer, Printer… and Account Book maker, 133 Praed St., London.’

This notebook has been divided into named sections. However, as it is a ring binder it is difficult to know if the papers are in the correct order or if sheets have been added later on.

Notebook includes:

Section one:

1. f. 2. The effect of salt on bactericidal power of blood on lysozyme and on emigration with NaCl; 23 June 1924.

2. ff. 4-5. The effect of hypotonic solution on bactericidal emigration and phagocytosis, including graphs; 20 May 1925.

3. ff. 6-12. Experiments to examine the effect of salt on lysozyme, in lined tubes, blood on bactericidal to staphylococcus, emigration and phagocytosis; 18 May 1925.

4. f. 13. The effect of neutral red and Brilliant Cresyl Blue on emigration; 19 May 1925.

5. ff. 15-19. Experiments with intravenous injections of NaCl, one was tested on a man; 13-31 March 1924.

6. f. 20. Intravenous injections of Chloramine T; n.d.

7. f. 21. Experiment involving intravenous injection of alcohol on bactericidal; 24 March 1924.

Section two: 12 March 1924-26 May 1925.

ff. 21-25. Salt.

i) Experiment examining the effect of salt on bactericidal power of blood

ii) Intravenous injection of salt into a rabbit

iii) Experiment using intravenous injection of KCl03 into rabbits to see if bactericidal increased

iv) Intravenous of basic fuschin into a rabbit

Section three: 2 Oct.-17 Dec. 1925.

ff. 26-35. Centrifuged agglutinations

i) Experiment to see if time after mixing and before centrifuging makes a difference to agglutination

ii) Centrifuged agglutination

iii) Experiment to examine the rate of union of agglutination and microbes

iv) Experiment to test the specificity of in vitro immunity

Section four: 5-16 Dec. 1925.

ff. 41-46, 49, 51. Ridley’s Movie Agglutinations

f. 47. Notes taken from an article on agglutination by J. L. Gates in Journal of Experimental Medicine, 35, 1922, p. 63.

f. 50. Notes from Medical Research Council Special Report No 51, including:

i) Report of committee upon pathological methods

ii) Physical condition influence agglutination

iii) Technique

iv) Dimensions of tubes

v) Absorption

Section five: 15 Jan. 1926, n.d.

ff. 52-55. Removal of Leucocytes

i) Notes on the removal of leucocytes from blood by filtration through cotton wool under pressure, includes notes on the technique and diagram of the apparatus

ii) Experiment testing de-leucocyted AF defibrinated blood.

Links with other notebooks:

56157: Phagocytosis, centrifuging and the removal of leucocytes from the blood

56162: Loose link with work on immunity in vitro

includes:

• ff. 2, 4-5 Pharmacology: Experiments and notes by A. Fleming rel. to bactericidal: 1902-1947, n.d.
• ff. 2, 6-12 Biochemistry: Experiments and notes by A. Fleming rel. to lysozyme: 1921-1948, n.d.
• ff. 2, 6-12, 15-19, 21-25 Chemical compounds: Experiments by A. Fleming rel. to salt: 1902-1925, n.d.
• ff. 4-12 Cell biology: Experiments by A. Fleming rel. to phagocytosis: 1902-1942.
• ff. 6-12 Bacteriology: Experiments and notes by A. Fleming rel. to staphylococcus: 1910-1947, n.d.
• ff. 6-12 Haematology: Experiments by A. Fleming rel. to blood: 1902-1947, n.d.
• ff. 6-13 Haematology: Experiments by A. Fleming rel. to emigration: 1925, n.d.
• ff. 15-19, 21 Scientific treatment: Experiments by A. Fleming using intravenous injections: 1924.
• f. 20 Pharmacology antiseptics: Experiments by A. Fleming rel. to chloramine T: 1925.
• ff. 26-35, 41-47, 49, 51 Haematology: Experiments by A. Fleming rel. to agglutination: 1902-1936, n.d.
• f. 50 Medical Research Council: Notes by A. Fleming for Special Report No. 51: n.d.
• ff. 51-55 Haematology: Experiments by A. Fleming rel. to leucocytes: 1917-1948, n.d.