Add MS 56170

FLEMING PAPERS. Vol. 22 March 1933-8 Feb. 1936.

ff. ii + 87. 276 x 223mm. Ring binder with hard brown cover. It was advertised as a ‘students’ ring book.

Label inside the front of the notebook is for ‘Isacke, Printer, Stationer, Account Book Maker. 133, Praed Street, W.2.’

As the notebook is a ring binder it is difficult to know if the papers are in the correct order. The notebook seems to have originally housed plain paper and this has been supplemented with other pieces of plain and lined paper.

A possible paper on ‘streptothrix’ has been removed and housed under publications; please see 56136 ff. 143-151.

Notebook includes:

Section one:

f. 2. Notes on the effect of heat on vaccines; n.d.

Section two:

ff. 8-11. Journal articles

i) Hektoen and Inoms - no title, Journal of American Medical Association, March 16, 864

ii) McIntosh, Modern Trend of Prophylactic Therapeutic Immunisation, Lancet, 1936, October 30, 889

iii) L. S. P. Dawson, no title, Lancet 1924, Dec. 20, 1288

iv) G. Schwartzman, Phage as an Antigen, Journal of Experimental Medicine, 1928, 47, 151

v) S. O. Freedlander and J. A. Jooney, Local intravenous Immunity to staphylococcus, Journal Experimental Medicine, 1928, 27, 663

Section three:

f. 11. References - Clasmolcytes in immunity

i) Say and Clark, Journal of Infectious Diseases, 1925, 36, 233

ii) Rous and Jones, Journal of Experimental Medicine, 1916, 23, 601

Gratia, CR Soc Biol, 1923, 89, 826

iii) Mallory and Marble, Journal of Experimental Medicine, 1925, 42, 465

iv) Z. Miller Hyg and [Intel?] 1927, 107, 253

v) Citron and Picard, Med. Klin., 1925, 43, 1606

Section four: 10 May 1933.

1. f. 15. Notes on a number of patients, their illnesses and results of experiments.

i) Gardner: O. P, rheumatoid arthritis

ii) Campbell Jones: WHW boils

iii) Pole: O. P, rheumatoid arthritis

iv) Walts: O. P, Catarrh

v) Powerland: O. P, P. N

Section five: 18-23 May 1933.

ff. 16-19. Formalin

i) On B. coli in broth

ii) Inhibitory power of formalin on B. coli

iii) Broth culture ‘King’ coli with varying strengths of formalin

Section six:

1. f. 20. Typhoid bactericidals; 23 May 1933.

2. f. 21. Paratyphoids from Salop Mental Hospital. Faeces planted in Brilliant Green and sent by post to him; 27 June 1933.

3. f. 22. Agglutination with paraB serum; 29 June.

4. f. 23. Notes on flagella and capsular stain from an article by Bartley in Journal of the Royal Medical Society 1931, p37.

5. ff. 25-26. 12-13 Sept. 1933.

i) Vos: acute sickness three days no pain or tenderness, did agglutination test and tests of urine, faces and post nasal swab

ii) Mayes: WHW recurrent catarrh

iii) Hall: sinuses, TB, emphysema and rheumatism

6. f. 27. Mycolysin -Tests with number of colonies picked off staphylococcus water plate which showed lytic area around it; 13 Sept.

7. f. 30. Development of inhibition substance ‘mould’; 29 Sept.-10^Oct.

8. f. 31. Various patients; 25 Oct. 1933.

i) Kyle: acne

ii) Simmonds: rheumatoid arthritis

iii) Shun: unknown complaint

iv) Bishop: O. P, rheumatoid arthritis

v) Plague cultures from Anglo Persians

9. f. 32. Experiment testing the agglutination of faecal streptococci with patients sera; 25 Oct. 1933.

10. f. 33. Notes on phenyl mercuric nitrate by K. E. [Bisklang], Journal Infectious Diseases, 1933, 53, 250.

11. f. 39. NaOH on staphylococcus; 6 Nov.

12. f. 43. Lysozyme on leucocytes, including diagrams, with ‘good’ written in pencil; 29 Dec. 1933.

Section seven: 30^{Dec. 1933-16 Oct. 1934.}

ff. 45-55. Merthiolate

i) Inhibitory action in broth and in agar (gutter method)

ii) Experiment with phenyl mercurcriate, methiolate, metaphor, mercurochrome and HgCl2

iii) Phenyl mercuric nitrate versus merthiolate

iv) Notes on phenyl mercuric nitrate by L. A. Weed and E. E. Ecker 1931, Journal of Infectious Diseases 49, 440

v) Merthiolate and Hg Phenyl Nitrals on haemolytic streptococcus in slide cells

Section eight: 3 March-5 Dec. 1934.

ff. 56-58, 60. Gentian Violet

i) Work on inhibition

ii) Experiments testing for a swab for isolating streptococci from staphylococcus

iii) Experiment testing staphylococcus and gentian violet

iv) Experiment with and without swab and slick on staphylococcus,

streptococcus mixture

Section nine:

1. ff. 61-62. Experiments with Brilliant Green and coli paratyphoid using the swab immersion method; 10 May 1934.

2. f. 63. Lysozyme, egg on coloured bacteria; 14 March 1934.

3. f. 66. McLean’s non lactose fermenter; 5 Sept. 1934.

4. ff. 69, 71, 73. New mould, including comparison with penicillin; 10-21 Dec. 1934.

Section ten: 23 Dec. 1934-18 Feb. 1935.

ff. 72, 75-76. Leucociden

i) Keeping power of penicillin

ii) Leucociden and antileucociden

iii) Leucociden on emigration

Section eleven:

1. f. 79. Eusol, iodine and phenol on penetration of bread and meat; 20 March 1935.

2. f. 82. Diagram of an agar plate showing the reaction of a sample taken from R. F’s nose 23 Jan.1936 with Pfeiffer, Pfeiffer separate coli, staphylococcus and staphylococcus separate coli; n.d.

1. f. 84. Diagram of an agar plate showing reaction of bacteria in Gough’s faeces with and without tellurite; 8 Feb. 1936.

Links with other notebooks:

56172: Phenyl mercuric nitrate (although dates differ)

includes:

• f. 2 Immunology: Experiments and notes by A. Fleming rel. to vaccines: 1902-1948, n.d.
• f. 8 Lancet; scientific journal: Notes by A. Fleming from an article by McIntosh entitled 'Modern Trend of Prophylacytic Therapeutic Immunisation': n.d.
• f. 10 Journal of Experimental Medicine: Notes by A. Fleming from an article by G. Schwartzman entitled 'Phage as an Antigen': n.d.
• f. 11 Immunology: References taken from journals by A. Fleming rel. to clasmolcytes in immunity: n.d.
• f. 11 Journal of Experimental Medicine: Notes by A. Fleming from an article by S. O. Freedlander and J. A. Jooney entitled 'Local Intravenous Immunity to Staphylococcus': n.d.
• ff. 15, 25-26, 31 Scientific method: Patient notes, including graphs, taken by A. Fleming: 1907-1948, n.d.
• ff. 16-19 Pharmacology antiseptics: Experiments by A. Fleming rel. to formalin: 1933.
• ff. 20-21, 61-62 Pathology infectious diseases: Experiments by A. Fleming rel. to typhoid and paratyphoid: 1908-1949, n.d.
• ff. 22, 32 Haematology: Experiments by A. Fleming rel. to agglutination: 1902-1936, n.d.
• f. 23 Bacteriology Proteus Vulgaris: Notes on flagella by A. Fleming: 1931-[1948]: Partly typewritten.
• f. 27 Biology: Experiments by A. Fleming rel. to mycology: 1930-1948.
• f. 30 Chemical process: Experiments by A. Fleming rel. to inhibition: 1917-1942.
• ff. 30, 69, 71, 73 Microbiology: Experiments by A. Fleming rel. to mould: 1929-1947, n.d.
• ff. 32, 82 Bacteriology: Experiments by A. Fleming rel. to streptococcus: 1921-1944, n.d.
• f. 33 Journal of Infectious Diseases: Notes by A. Fleming on phenyl mercuric nitrate from an article by []: n.d.
• ff. 33, 45-55 Chemical compounds: Experiments by A. Fleming rel. to phenyl mercuric nitrate: 1934-1936, n.d.
• ff. 39, 82 Bacteriology: Experiments and notes by A. Fleming rel. to staphylococcus: 1910-1947, n.d.
• f. 43 Haematology: Experiments by A. Fleming rel. to leucocytes: 1917-1948, n.d.
• ff. 43, 63 Biochemistry: Experiments and notes by A. Fleming rel. to lysozyme: 1921-1948, n.d.
• ff. 45-55 Pharmacology antiseptics: Experiments by A. Fleming rel. to merthiolate: 1933-1934.
• ff. 56-58, 60 Pharmacology antiseptics: Experiments by A. Fleming rel. to gentian violet: 1927-1942.
• ff. 61-62 Pharmacology antiseptics: Experiments by A. Fleming using Brilliant Green: 1915-1934.
• ff. 69, 71, 73 Microbiology penicillin: Experiments and notes by A. Fleming: 1928-1949, n.d.
• ff. 72, 75-76 Haematology: Experiments by A. Fleming rel. to leucociden: 1935.
• f. 79 Pharmacology antiseptics: Experiments and notes by A. Fleming: 1916-1949, n.d.
• ff. 82, 84 Bacteriology: Experiments, notes and photographs by A. Fleming rel. to bacteria: 1928-1947, n.d.