Add MS 56171

FLEMING PAPERS. Vol. LXVI. 1 April-14 Dec.1935.

ff. ii + 225. 326 x 207mm. Charles Lett’s ‘self-opening’ diary for 1935, with a hard, cream cover with red binding.

A large number of pages have been cut out of the notebook.

Notebook includes:

Section one: n.d.

ff. 18-22.

i) Photograph of a church spire or the tower of a building (possibly St

Mary’s)

ii) Image of Fleming in his laboratory

iii) Could be a rough contents list

iv) Notes on tellurite – broth, anaerobes and colours in broth

iii) Photograph of an unidentified man in St Mary’s laboratory

Section two: 1–9^April.

ff. 72-76. Leucociden

i) Emigration in cells

ii) Mixtures made in capillary pipettes

Section three:

1. ff. 79v-80. Experiments with penicillin and staphylococcus using Dettolin, strips of filter paper and killing in saliva; 16-17 April.

2. f. 87. Cough and sneeze plates from patients – Saltmarsh, Baker (acne), Birch, O’Brien, Poll, Turner, Mace, Taylor, Allen, Smith, Cohen and Bond; 1 May.

3. f. 90v. Dellotin experiments with various tubes; 8 May.

Section four: 13 May-5 June.

ff. 93v-94, 98v-99. Staphylococcus

i) Toxin production from boil patients on 1 May

ii) Experiment with agar and penicillin and streaks of staphylococcus added, includes diagram and same technique with streptococcus

iii) Samples isolated from students and nurses, throats and fingers

Section five: 17-26^June.

ff. 112v, 117v-118. Tellurite

i) Typhoid in broth

ii) Coli plates

iv) Anaerobes in glucose agar

Section six: 9 July.

f. 124v. Sedimentation

i) Different calibres of tube – length of columns about equal

ii) Different lengths of tube – same calibre

iii) Regularity of tube

Section seven: 11-18 July.

ff. 125v-127v, 129. Dettolin

i) Antiseptic power

ii) In blood on slide cells

iii) As a cleaner

iv) Destruction in mouth wash compared with eusol

Section eight:

1. f. 128. Formaldehyde on staphylococcus; 16 July.

i) Killing strong suspension

ii) Inhibition

2. f. 131v. Rowe – agglutination after protein stock; 23 July.

Section nine: 24 July-7 Oct.

ff. 132, 161v-166v, 169v-170. Tellurite

i) Coloured contaminants

ii) On coli – including two diagrams pf agar plates

iii) Diagram of agar plate showing 1/million tellurite agar

iv) Development of tellurite resistance

v) Coli required resistance to tellurite

vi) Induced tellurite resistance to coli

Section ten:

1. ff. 183v-185. Staphylococci from students: Pollard, Spencer, Spicer, Cohen, Hallow, Perry, Berry, AF, Jenner, Smith, Hodlisone, Fell, Kahlengh, Scott, Jones, Glazier, Lawson, Hyson and Peter (lab); 4-6 Nov.

2. f. 185v. National collection coliforms. Tellurite on agar, planted from solid cultures; 8 Nov.

3. ff. 198v-200. Patient Burton (unknown condition); 5 Dec.

i) Inoculated with staphylococcus

ii) Various tests – agglutination, precipitation and bactericidal power of serum

1. f. 205v. Shiga agglutination using fresh serum; 16 Dec.

Links with other notebooks:

56160 and 56169: Tellurite (although dates differ)

includes:

• ff. 18-22, 112v, 117v-118, 132, 161v-166v, 169v-170, 185 Pharmacology antiseptics: Experiments by A. Fleming rel. to tellurite: 1932-1937, n.d.
• f. 19 Art. Photographs: London; Secular Institutions. HOSPITALS AND CHARITABLE INSTITUTIONS. St. Mary's Hospital: Photograph of A. Fleming in his laboratory: n.d.
• f. 27 Art. Photographs: London; Secular Institutions. HOSPITALS AND CHARITABLE INSTITUTIONS. St. Mary's Hospital: Photograph of an unidentified man in one of the Inoculation Department's laboratories: n.d.
• ff. 72-76 Haematology: Experiments by A. Fleming rel. to leucociden: 1935.
• ff. 79-80 Microbiology penicillin: Experiments and notes by A. Fleming: 1928-1949, n.d.
• ff. 79-80, 93v-94, 98v-99, 128, 183v-185 Bacteriology: Experiments and notes by A. Fleming rel. to staphylococcus: 1910-1947, n.d.
• f. 87 Scientific method: Notes by A. Fleming on cough and cold plates taken from patients: 1935.
• ff. 90, 125v-127v, 129 Pharmacology antiseptics: Experiments by A. Fleming rel. to dettolin: 1935.
• f. 124v Chemical process: Experiments by A. Fleming rel. to sedimentation: n.d.
• f. 128 Chemical process: Experiments by A. Fleming rel. to inhibition: 1917-1942.
• ff. 131v, 198v-200, 205v Haematology: Experiments by A. Fleming rel. to agglutination: 1902-1936, n.d.
• ff. 198v-200 Chemical process: Experiments by A. Fleming rel. to precipitation: 1932-1940.
• ff. 198v-200 Pharmacology: Experiments and notes by A. Fleming rel. to bactericidal: 1902-1947, n.d.
• ff. 198v-200 Scientific method: Patient notes, including graphs, taken by A. Fleming: 1907-1948, n.d.