Add MS 56172

FLEMING PAPERS. Vol. LXVII. 7 Jan.-21 Dec.1936.

ff. i + 222. 324 x 201mm. Collin’s Scribbling Diary for 1936, with a hard, green cover and red binding.

Notebook includes:

Section one: 7–9^Jan.

ff. 14v-15v. Experiments with shiga serum

i) Agglutination

ii) Dilution of serum

iii) Acetone extracted suspension

iv) Serum on slide with old cultures of bacteria

v) Serum on stock emulsions

Section two:

1. f. 23. Peroxide on staphylococcus and pneumococcus; 28 Jan.

2. f. 26. Agglutination: Rowe and Wallis; 3 Feb.

3. ff. 32-40v. Toxicity of staphylococcus; 15 Feb.-3 March.

4. ff. 42-43. Paper on gonococcus soluble toxin (Corbus –Ferry), written ‘To the Medical Profession’. It contains background information and notes on dosage for adults and children, local treatment and packages. It may have been a trial for Parke, Davis & Company; 6 March.

5. ff. 72-72v. List of patients and samples taken from them, notes include identification of bacteria; 29^March.

i) Dowling: pus

ii) Predner: O. P, sputum

iii) Morgan: O. P, boil

iv) McEdward: O. P, faeces

v) Scrap: O. P, P. N.

vi) Brockliss: P. N, faeces

vii) Young: serum

6. f. 74v. Experiments heating serum, for long and short periods (45 sec, 30sec etc); 4 May.

7. f. 79. Diagram of a streak test on agar plate with tellurite and penicillin on fm-cocci; 7 May.

8. f. 80v. Experiment with stick anaerobes, planted from meat to glucose broth and grown in three days; 10 May.

9. ff. 83, 84v-86. Action of pot chromate and biochromate on coli; 15-19 May.

10. ff. 90v-91. Experiments with tellurite resistance and the effect of tellurite and penicillin on paper, includes a diagram; 28-29 May.

11. ff. 102v-103. Induced resistance coli to tellurite; 21 June.

12. f. 103v. ‘Prawn’ variants of resistant to penicillin, includes diagrams (straight away and after three days), 23^June.

13. f. 107v. Notes for a Congress on selective bacteriostasis (all with diagrams of plates); 29 June.

i) Lysozyme

ii) Penicillin

iii) Tellurite

This work may have a link to a paper on selective culture that he gave to Second Congress of Microbiology, London 1936.

Section three: 9-11 Sept.

ff. 141v-143. Experiments with phenyl mercury nitrate

i) Dilutions in water

ii) Inhibitory action in small test tubes

iii) Whether inhibitory results are same for slide cells, capillary tubes and test tubes

iv) Saliva and capillary tubes

v) On haemolytic streptococcus in slide cells

Section four: 1-12 Oct.

ff. 152v, 154v-155, 158-160. Leucocytes

i) Anti-leucociden

ii) Filtered and unfiltered

Section five: 23 Oct.-21 Dec.

ff. 165v-168, 170v-174, 175v-176v, 181v-183v, 186v, 187v, 188v-191, 192v-199, 202v-207, 208v-209-209. Sulphonamide

i) Slide cells

ii) Capillary tubes

iii) Planted in broth and diluted 1/10 with de-leucocyted blood

iv) Slide cells – a. a, blood and chemicals

v) Three diagrams showing effect on blood (different dilutions)

vi) Staphylococcus in blood

vii) Hughes rabbit experiment

viii) In staphylococcus cells

ix) Influence of different complaints with Richards streptococcus

x) Different implants of Richards

xi) Fixation

xii) Injections into a rabbit

xiii) In slide cells with three different streptococci (includes photo and diagrams)

xiv) Absorption by streptococcus

Section six:

1. f. 216. Hand drawn maps

Links with other notebooks:

56170: Phenyl mercuric nitrate (although dates differ)

56173: Sulphonamides (although dates differ, probably more a continuation of work)

includes:

• ff. 14v-15v, 74v Haematology: Experiments by A. Fleming rel. to serum: 1902-1947, n.d.
• f. 23 Bacteriology: Experiments by A. Fleming rel. to pneumococci: 1902-1939.
• ff. 23, 32-40v Bacteriology: Experiments and notes by A. Fleming rel. to staphylococcus: 1910-1947, n.d.
• f. 26 Haematology: Experiments by A. Fleming rel. to agglutination: 1902-1936, n.d.
• ff. 42-43 Parke Davis & Company; pharmaceutical company: Paper by A. Fleming on gonococcus soluble toxin, possibly from a trial, 6 March: 1936.
• ff. 72-72v Scientific method: Analysis of samples from patients taken by A, Fleming, some of which include a description of their complaints: 1929-1944, n.d.
• ff. 79, 90v-91, 102v-103, 107v Pharmacology antiseptics: Experiments by A. Fleming rel. to tellurite: 1932-1937, n.d.
• ff. 79, 90v-91, 103v, 107v Microbiology penicillin: Experiments and notes by A. Fleming: 1928-1949, n.d.
• f. 107v Second Congress of Microbiology; London: Notes by A. Fleming on selective bacteriostasis, possibly for a paper for the Congress: 1936.
• f. 107v Biochemistry: Experiments and notes by A. Fleming rel. to lysozyme: 1921-1948, n.d.
• ff. 141-143 Chemical compounds: Experiments by A. Fleming rel. to phenyl mercuric nitrate: 1934-1936, n.d.
• ff. 152, 154v-155, 158-160 Haematology: Experiments by A. Fleming rel. to leucocytes: 1917-1948, n.d.
• ff. 165v-168, 170v-174, 175v-176v, 181v-183v, 186v, 187v, 188v-191, 192v-199, 202v-207, 208v-209 Pharmacology: Experiments by A. Fleming rel. to sulphonamides: 1936-1942.