Add MS 56177

FLEMING PAPERS. Vol. LXXII. 9 Oct. 1945-10 Oct. 1947.

ff. ii + 107. 320 x 200mm. Hard red cover with red binding.

Label on the front has ‘PENICILLIN 9^th October, 1945’ written on it.

Label inside the back cover for ‘W. Isacke, Printer, Stationer, Account Book Maker. 133, Praed Street, W.2.’

Most of the work in this notebook is focused on penicillin, with experiments based on samples taken from individuals. Fleming has noted the name of the person, where the samples were taken from on the body and a description of the bacterium’s growth. The notebook also houses notes on other experiments that are linked with penicillin.

Notebook includes:

Section one: ff. 1-6.

i) Two copies (photograph/ photocopy) of a list of staphylococci from normal skin, etc

ii) Two copies (photograph/ photocopy) of a list of staphylococci from definite lesions

iii) Two copies (photograph/ photocopy) of the summaries of the above tables

Section two: Penicillin lozenges

1. f. 17. Parke Davis and Company and Boots and Co, notes include a description of tests of their potency; 28 Nov. 1945.

2. f. 33. From supply of 21 Dec. 1945, kept in ice chest and at room temperature, each tablet 500 units then diluted by 1/10 to 50 units, testing for potency and found that they are full strength; 20 March 1946.

3. f. 33v. From supply of November, two tablets from ten different bottles, crushed and dissolved in 100cc of saline, found that they lost 50% of their potency; 22 March 1946.

Section three: 23 March 1946.

f. 34. Inhalation

i) Sputum – diluted 1/10 in saline and placed in bath 60˚C for 20 minutes and titrated

ii) 10 units per cc

iii) 3-3½ units per cc

Section four:

1. ff. 42v-43v. 100,000 tested blood levels and urine; 15-17 May 1946.

2. ff. 43v-44. 100,000 in 3cc; 30 May 1946.

3. f. 44v. 100,000; 5 June 1946.

4. f. 45. Graph showing the inhalation of 240,000; 6 June.

5. f. 47. 100,000; 20 June 1946.

6. f. 51v. 60,000 by 3 hourly by injection; 6 Aug. 1946.

7. ff. 52-53v. Blood penicillin.

8. f. 57v. Blood penicillin 100,000 subcutaneously; 20 Sept. 1946.

9. f. 58. Guinea pigs injected with benzyl penicillin; 22 Sept. 1946.

10. ff. 63v-64. Tests with ‘phantoveiza’ apparatus for inhalation of penicillin. Concluded apparatus produced rapid destruction of penicillin within a few minutes; 30 Oct. 1946.

11. f. 65v. Effect of nickel and ebonite on penicillin; 7 Nov. 1946.

12. f. 66v. 11 Nov. 1946.

i) Test effect of ‘Rybourin’ inhalant solution on the stability of penicillin

ii) Test effect of a local antiseptic for dental use on penicillin

includes:

• ff. 1-6 Bacteriology: Experiments and notes by A. Fleming rel. to staphylococcus: 1910-1947, n.d.
• ff. 17, 33-34, 42v-45, 47, 51v, 52-53v, 57v, 58, 63-66v Microbiology penicillin: Experiments and notes by A. Fleming: 1928-1949, n.d.
• ff. 42v-43v, 52-53v, 57v Haematology: Experiments by A. Fleming rel. to blood: 1902-1947, n.d.
• ff. 63-64 Scientific equipment: Tests by A. Fleming with a 'phantoveiza' for its use as an aid for the inhalation of penicillin: 1946.
• f. 66 Pharmacology antiseptics: Experiments and notes by A. Fleming: 1916-1949, n.d.