Add MS 56224

FLEMING PAPERS. Vol. CXIX. 5 Sept.1928-10 March 1930.

ff. iii + 168. 321 x 200mm. Hard green cover with red binding.

Notebook of Dr. S. Craddock when he was based at St. Mary’s Hospital, Paddington.

Inside the front cover is a label for ‘W. Isacke, Account book maker, 133, Praed Street, London, W.2’

Craddock collaborated with F. Ridley on some of the experiments in the notebook.

Notebook contains numerous markers; these are in Fleming’s handwriting.

Notebook includes:

Section one:

1. f. iii. Letter to Craddock from E. Little relating to a culture from a patient; n.d.

2. f. 4. Piece of paper with notes n Champion and other patients; n.d.

3. ff. 21-22v. Effect of HgCl2 on various microbes; 5 Sept. 1928.

4. ff. 23-24. Reaction in slide cells; 11 Sept. 1928.

5. f. 25v. Effect of HgCl2 on leucocytes after intervals, 25 Sept. 1928.

6. ff. 27-28v. Action of flavine on leucocytesant intervals.

7. f. 28. Coli in slide cells, includes diagrams.

8. ff. 30-31. Effect of HgCl2 injected into a rabbit; 9 Oct. 1928.

9. ff. 31v-33. Effect of HgCl2 on human blood; 12-17 Oct. 1928.

10. ff. 33v-34. Effect HgCl2 injection into a rabbit.

11. f. 35. Action of sulphonamide 468 and sulphonamide 36 on Allen II and haemolytic II; 16 Dec. 1928.

12. f. 35v. Effect of mould extract on bactericidal growth.

13. f. 36v. Effect of mould extract on II pyog.

14. f. 37. Effect of dilutions of anthrax; 2 Jan. 1929.

15. f. 38v. Effect of mould juice on time of killing and Pfeiffer’s.

16. f. 39. Testing formalin ‘drops’ used for ears on O. P.

17. f. 39v. Effect of keeping blood in:

i) Incubator

ii) Ice chest

18. f. 40. To show the effect of variations in strength of inoculation of staph in mould juice; 28 Jan. 1929.

19. ff. 41v-45. Testing various mould groups; 6-16 Feb. 1929.

20. ff. 46. Results of slide cells with anthrax, etc; 19 Feb. 1929.

21. ff. 48-49. Slide cells and mould juice; 26 Feb. 1929.

22. ff. 50-51. Testing mould juice: 4-8 March 1929.

i) Different pH values

ii) After boiling

iii) On blood

23. ff. 56-57v. Extracting mould active inhibitor; 20-21 March 1929.

24. f. 55v. Injecting mould juice into a rabbit; 22 March 1929.

25. f. 59. Penetration of mould juice into tissues; 2 April 1929.

26. ff. 60-62. Experiments with mould juice; 3-9 April 1929.

27. ff. 62v-63. Extraction; 10-29 April 1929.

i) Lead vaccine

ii) Evaporation

28. ff. 64-65. Attempt to get resistant strain from mould by heating; 16 April 1929.

29. f. 66. Effect of heat; 7 May 1929.

30. f. 67. Experiment to prove whether or not there is an enzyme which causes the mould juice to deteriorate; 21 June 1929.

31. f. 67v. Method of keeping the mould juice in good preservation; n.d.

32. ff. 68-68v. Method of growing mould with more protein and salt; n.d.

Section two: 3 Feb. 1930, n.d.

1. ff. 71-81. Acne

i) Isolation of acne (using penicillin)

ii) From pus

iii) Tests on patients

iv) Acne and sugars

v) Planted in glucose broth and Vaseline

vi) Mice

2. ff. 81v-83v. List of patients, samples taken from them and notes on the bacteria’s growth.

Section three:

1. ff 100v-101. Tests serum of rabbit; n.d.

2. f. 102. Record of twenty cases of normal people nose squeezed, record of the amount of juice produced and type of bacteria it contained; n.d.

3. f. 105. Classification of B. acne for sugars; n.d.

4. ff. 111-113. The use of penicillin to obtain pure primary culture of the acne bacilli; n.d.

5. f. 157. Photograph of a plate with colonies on it; n.d.

Links with other notebooks:

56141, 56144, 56173: Acne

56148, 56156 and 56159: HgCl2

Stuart Craddock, physician: Notebook of: 1928-1930.

includes:

• f. iii Stuart Craddock, physician: Letter from E. Little rel. to a culture from a patient: n.d.
• ff. 21v-22v, 25v, 30-34 Pharmacology antiseptics: Experiments by S. Craddock rel. to mercuric chloride (HgCl2): 1928.
• ff. 23-24, 28, 46, 48-49 Scientific method: Experiments by S. Craddock rel. to slide cells: 1928-1929.
• ff. 25v, 27-28v Haematology: Experiments by S. Craddock rel. to leucocytes: 1928.
• ff. 27-28v Pharmacology antiseptics: Experiments by S. Craddock: 1928.
• ff. 31v-33, 39v Haematology: Experiment by S. Craddock rel. to blood: n.d.
• f. 35 Pharmacology: Experiments by S. Craddock rel. to sulphonamides: 1928.
• ff. 35v-36 Pharmacology: Experiment by S. Craddock rel. to bactericidal: n.d.
• ff. 35v-36v, 38v, 40-45, 48-51, 56v-57v, 59-62, 64-65, 67-68 Microbiology: Experiments by S. Craddock rel. to mould: 1928-1929, n.d.
• ff. 36v, 38v, 40, 48-49, 102, 157 Bacteriology: Experiments by S. Craddock rel. to bacteria: n.d.
• ff. 37, 46 Pathology infectious diseases: Experiments by S. Craddock rel. to anthrax: 1929.
• f. 39 Pharmacology: Experiments by S. Craddock rel. to formalin 'drops': n.d.
• ff. 71-83v, 103v-104, 111-113 Pathology dermatological diseases: Experiments by S. Craddock rel. to acne: 1930, n.d.
• ff. 81-83 Scientific method: Patient notes by S. Craddock, including bacteria produced from samples: n.d.
• ff. 100-101 Haematology: Experiments by S. Craddock rel. to serum: n.d.
• ff. 111-113 Microbiology penicillin: Experiments by S. Craddock: n.d.