Add MS 56225

FLEMING PAPERS. Vol. CXX. 10 Feb.-14 Sept. 1938.

ff. ii + 144. 323 x 199mm. Hard green cover with red binding.

Notebook in an unidentified hand, with a few loose papers in Fleming’s hand.

Label inside the front cover for ‘W. Isacke, Manufacturing Stationer and Printer, 133, Praed Street, W.2.’

Notebook includes:

1. ff. 1-1v. List of staphylococcus. Samples have been given a number, date of isolation, name, colour and lesion; n.d.

2. f. 2. Toxin production in rabbits.

3. f. 3. Coagulase production in humans and rabbits.

4. ff 3v-4v. Toxin production (sheep) B. toxin.

5. f. 5. Experiment with interaction of staph toxin and N. human serum.

6. ff. 6-7. Effect of autolysed staph extract.

7. ff. 11-19. Diagram of experiments with different numbered bacteria from the list on ff. 1-1v. Plus notes about the success of the experiment.

8. ff. 20-22. Three pieces of A4 card with information about bacteria, date of isolation, name of patient taken from, lesion, colour and ability to coagulate; n.d.

9. ff. 32-51. Notes on experiments with a range of bacteria, possibly linked to samples in the notebook (ff.1-1v) and on the piece of card (ff. 18-20).

10. f. 54v. Staph growth on clear serum agar; 3 March 1938.

11. f. 55. Selected staph growth on agar in 6cc of immune rabbit serum grown in air and CO2; 3 March 1938.

12. f. 57. Experiment with clear agar and control of ordinary serum agar plate; 7 March 1938.

13. f. 57v. Staph growth in serum agar using N. H. S, kept in a boiling water bath for two minutes, grown in air, 37˚C; 8 March 1938.

14. f. 61. Selected staph grown in N. human serum at 37˚C in air and CO2; 15 March 1938.

15. f. 63. Selected staph grown in serum agar and hydrocoche fluid in air and CO2 at 33%; 17 March 1938.

16. ff. 65v-70. Experiments with:

i) Borough’s Wellcome antitoxin

ii) Davis Parke Serum

iii) Carbohydrate serum

17. f. 71. Notes on halo’s produced by the staphylococci.

18. f. 72. Notes in variation of halo.

19. f. 83. Experiment with No. 46 Nuchoprotein; n.d.

20. ff. 85-87. Notes on the pathogenicity of staph in nose and throat; n.d.

21. f. 88. Experiment with a plate containing 3ccs of rabbit antityphoid serum, titre 1/10,000 typhoid, ParaA, coli and staph and Allens, grown for twenty four hours at 37˚C; 5 May 1938.

22. ff. 90-91. Experiment with ‘683’ and blood; n.d.

23. f. 92. Rate of growth of streptococci.

24. f. 96. Notes on how to extract staphylococcus carbohydrate.

25. ff. 112, 117-118. Photograph of a plate with staphylococci on N. human serum agar grown in air for three days; 11 Feb. 1938.

26. f. 113. Sheet of paper from a calendar dated 3^{Jan. 1938 with notes on the autolysis; n.d.}

27. ff. 114-116. Three untitled photographs of plates with colonies on; n.d.

28. ff. 137-140, 142-145v. Penicillin titration.

Links with other notebooks:

56179, 56175, 56176: Penicillin titration

includes:

• ff. 1-1v, 5-7, 54v-55, 57v, 71, 85-88, 96, 112, 117-118 Bacteriology: Experiments and photographs by an unknown individual rel. to staphylococcus: 1938.
• f. 3 Haematology: Experiment by an unknown individual rel. to coagulation: 1938.
• ff. 5, 55, 57-57v, 61, 63, 65v-70, 88, 112, 117-118 Haematology: Experiments and photographs by an unknown individual rel. to serum: 1938.
• ff. 11-22, 32-51, 88, 114-116 Bacteriology: Experiments by an unknown individual rel. to bacteria: 1938.
• f. 88 Pathology infectious diseases: Experiment by an unknown individual rel. to typhoid: 1938.
• ff. 90-91 Haematology: Experiments by an unknown individual rel. to blood: 1938.
• f. 92 Bacteriology: Experiment by an unknown individual rel. to streptococcus: 1938.
• ff. 137-140, 142-145 Chemical process: Experiments by an unknown individual rel. to titration: 1938.
• ff. 137-145 Microbiology penicillin: Experiments by an unknown individual: 1938.