Add MS 84126

Four card folders and two separate sheets.

Card folder 1: 'POLYMORPH – POSSIBLE MECHS'

1. Notes, black ballpoint and pencil (f. 1), GRMSIM. 'How to distinguish between increase in fitness at low frequency & fall in fitness at high frequency'.

2. Notes, black ballpoint and blue ballpoint (f. 2), 'HYPOTHESES AND PLANS'. Frequency-dependent selection, heterozygote deficiency, polymorphism, heterosis, rare alleles.

3. Notes, blue ballpoint (f. 3), mathematical workings. Fluctuating selection.

4. Notes, black ballpoint (f. 4), mathematical workings. Mean fitness of allele.

5. Reference card, blue ballpoint (f. 5), note on bibliographic reference. 'Crow and Kimura on random drift'.

6. Notes, blue ballpoint and pencil (f. 6), arithmetic.

7. Notes, handwritten (ff. 7-9), mathematical workings. Hardy-Weinberg. Frequency-dependent increase in fitness.

8. Notes, blue ballpoint (ff. 10-11), mathematical workings.

9. Notes (f. 12), black ballpoint, 10 July 1973, beginning: 'If the difference between, say, 3 and 4 provided much selection pressure, then selection would push frequency closer toward equality'.

Card folder 2: 'Polymorphism – General Thoughts, Approaches'

1. Notes, black ink, pencil (f. 13), 'Anthony Edwards'. ?A. W. F. Edwards, population geneticist.

2. Notes, blue ballpoint (f. 14), 'Why is there generally little few cases of both common & rare allele polymorphism?'

3. Notes, blue ballpoint (f. 15), 29 November 1973. List itemising things to do.

4. Notes, blue ballpoint (f. 16), 28 and 29 November 1973. 'How much H-W deviation from general selection for heterozygosity-?'.

5. Notes, blue ballpoint (ff. 17-18), 26 November 1973. 'Suppose we have marked, non-heterotic survival selection & heterotic reproductive selection. How to detect?'.

6. Notes, blue ballpoint (ff. 19-21), 24 November 1973. 'Correlation studies among different loci', 'Correlation matrix', 'Factor analysis'.

7. Notes, blue ballpoint (f. 22).

8. Notes, blue ballpoint (f. 23), 'pleiotropism'.

9. Notes, black ballpoint and blue ballpoint (f. 24), 'Association may come from Linkage[,] Selection[,]… Bottleneck…'. 'Age changes in gene frequency'. 'Hardy-Weinberg deviations - may be from post-conceptual selection'.

10. Notes, handwritten (ff. 25-26), 'Questions for Hoppy'. ?D. A. Hopkinson.

11. Notes, pencil (f. 27), list itemising types of numerical variables, parameters.

12. Publisher’s abstracts of books, including Robert Creed (ed.), Ecological genetics and evolution. Essays in honour of E. B. Ford (Blackwell Scientific Publications) with pencil marginal line (f. 28).

13. Notes, pencil (f. 29).

14. Notes, black ballpoint (f. 30), things to do. 'Typewriter ribbon changed - ?' 'How to get a stronger effect – with more inbreeding depression'.

15. Notes, pencil (f. 31), outline list: 'The problem', 'Versatility Selection', 'The model – Multi-loci', 'Properties' and 'Tests'.

16. Notes, blue ballpoint and pencil (f. 32): 'Genes controlling genetic mechanism? Break down the dogma of isolation of germ plasma-'.

17. Notes, blue ballpoint (f. 33), mathematical workings.

18. Notes, handwritten: one small sheet, three intermediate and one A4 sheet (ff. 34-38). Mathematical workings.

19. Labels, pencil (ff. 39-43).

20. Pad of paper, blue ballpoint (ff. 44-53): 'Program for Hardy-Weinberg deviations'.

Card folder 3: 'The General Polymorphism Program'

1. Notes, handwritten (ff. 54-56), 'Polymorphism measures'.

2. Notes, handwritten (ff. 57-58), possible schemes for calculating suitable values.

3. Notes, handwritten (ff. 59-63), fluctuating selection, genetic polymorphism, sexual selection.

4. Notes, pencil (f. 64).

5. Notes, black ballpoint (f. 65).

6. Notes, handwritten (ff. 66-76), planning for computer programming, frequency distribution statistics, FORTRAN IV.

7. Coding form, University of London Fortran Coding Form (f. 77). One line entry in pencil.

Card folder 4: 'GENERAL PLAN'

1. Notes, blue ballpoint (f. 78), 'GPANAL', computer program planning.

2. Pad of blue paper with notes, handwritten (ff. 79-83): 'SPSS plus any new scattergram system', 'KCDIST and NAGFUN', 'GPMSIM', 'GPANAL', planning for computer programming.

3. Notes, pencil on blue paper from pad of blue paper (f. 84): 'TO DO – May 6th and 7th'. List of tasks, from (1) to (9), relating to planning for computer programming.

4. Notes, handwritten (ff. 85-89), mathematical workings, computer planning.

6. Notes, handwritten (ff. 90-92), computer planning.

Two separate notes (ff. 93-94): (1) 'May 6th run' (blue ballpoint and pencil); (2) 'Question: With iso-alleles, are the average allele frequencies proportional to their mutation rates? (black ballpoint and red ballpoint).